Endocrine Abstracts

Thyroid cancer (TC) is one of the most frequent neoplasia diagnosed in general population with an estimated incidence of 6.6 cases per 100.000 and mortality of 0.43 cases per 100.000. Differentiated thyroid cancer (DTC), which includes papillary (PTC) and follicular cancer (FTC), comprises the large majority (up to 90%) of all thyroid cancer cases. At the moment etiology of TC is not completely understood, with multiple genetic and epigenetic factor that are thought to be impo...

Background: levothyroxine is the most common medication for the treatment of hypothyroidism. Usually, it is capable of restoring euthyroidism in most conditions. Absorption can be challenging, therefore different formulations are available (tablet, soft gel, liquid). Rarely it is necessary to use liothyronine to achieve normal TSH values.Clinical case: a 23 y/o woman was admitted to our outpatient clinic for severe hypothyroidism. She was diagnosed with ...

Background: Dopamine agonists (DA) are included in the management algorithm of acromegaly. Studies on cabergoline monotherapy report IGF-1 normalisation in between 0% and 100% of the patients during treatment periods ranging between 2.6 and 24 months. However, in many of these studies, previous radiotherapy is a confounding factor. Furthermore, real world data applying the current disease control criteria (normal IGF-1 and GH<1 mg/l) are not available. The aim of this stud...

Background: Obesity represents a threatening worldwide epidemic but, beyond the guidelines recommendations, its modalities of treatment in the medical community appear as variable and not clearly defined. Aim of our survey was to assess the present real-world approach to obesity management in Italy.Methods: Online anonymous survey among the 2248 members of the Italian Association of Clinical Endocrinologists (AME). The survey included 8 questions about d...

Background: Cabergoline monotherapy or in combination with somatostatin analogue (SSA) has been reported in few studies with IGF-1-normalization-rates 0%-100%(monotherapy) and 42%-60%(combination therapy). However, in these studies, inclusion of irradiated patients is a potential confounder and currently proposed disease control criteria (normal IGF-1, GH<1 mg/l) have not been applied.Aim: Investigate the efficacy of cabergoline monotherapy or as add...

Background: Overweight and obesity are an increasing concern for public health worldwide. Obesity is a chronic, progressive and relapsing disease associated with the development of several comorbidities which may improve after weight loss. The first step in the management of weight excess includes life-style modifications but, in the long-term, obesity is frequently resistant to life-style changes only. Surgical procedures and medical treatments have, therefore, been developed...

Introduction: Cabergoline is one of the medical treatments in acromegaly; it can be used alone or in combination with other available agents.Aim: To review the efficacy of cabergoline in patients with acromegaly treated in our centre.Patients and methods: Patients with acromegaly on cabergoline were identified from our Pituitary Registry. Clinical/laboratory/imaging data were collected and analysed.Results: F...

Aim: Diagnostic definition and therapeutic interventions for nodular thyroid disease represent a high healthcare cost and their consequences may have a negative impact on quality of life of patients. This guideline aims at providing a reference for the management of non-functioning, benign thyroid nodules causing local symptoms in adults outside of pregnancy. The purpose is to standardize the treatment, based on the evidence provided by the GRADE method and the expertise of a ...

Background: Thyroid nodules are the most common endocrine pathology. Due to the widespread use of imaging modalities, mostly ultrasound, the incidental finding of thyroid nodules has increased, reaching a prevalence of 50-60% in adults. Diagnostic definition and therapeutic interventions represent thus an increasing cost for health system. In patient with benign thyroid nodule causing local symptoms, hemithyroidectomy with isthmectomy or total thyroidectomy are the recommended...

Background: Given the high prevalence of Nonalcoholic Fatty Liver Disease (NAFLD) in clinical endocrinology, diabetology, and primary care practice, international societies have addressed guidelines to drive clinicians in screening, diagnosis, and treatment for this condition.Aim: compare the most recent guidelines to address similarities and differences and help clinicians choosing the most updated evidence. We considered Italian guidelines (2021), AACE...